What causes perforating collagenosis?
The underlying cause of reactive perforating collagenosis is unknown, but an abnormal response to superficial trauma (eg, scratching) may be involved. Papules have been reported following scratches, acne spots, insect bites, and scabies.
Is perforating collagenosis curable?
Familial reactive perforating collagenosis is a lifelong condition with lesions becoming larger and more numerous with age. Individual lesions in both the familial and acquired forms are self-healing but often recur.
What causes acquired perforating dermatosis?
Acquired perforating dermatosis is a chronic disease, usually associated with diabetes mellitus or renal failure or both. In patients receiving dialysis, acquired perforating dermatosis occurs in about 10% of patients. It is also rarely associated with liver disease, malignant disease, hypothyroidism and HIV.
How do you treat perforating folliculitis?
Tretinoin 0.1% cream has cleared some perforating folliculitis lesions but has not prevented the development of others. A case of successful treatment using 13-cis -retinoic acid has been reported. A 2004 study of 5 perforating folliculitis patients showed good clinical responses with narrowband UV-B therapy.
What is Collagenosis?
A connective tissue disease (collagenosis) is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs.
How is perforating dermatosis treated?
Most medical literature on the treatment of ARPD is limited to individual case reports and small series of patients. Various therapies that have been tried include antihistamines, topical keratolytics, corticosteroids, tretinoin, oral drugs such as allopurinol or antibiotics, and phototherapy or photochemotherapy.
What is perforating folliculitis?
In perforating folliculitis, keratotic follicular papules develop, particularly over extensor surfaces. Microscopically, the disorder is characterized by disruption of the infundibular portion of the follicular wall, with transepidermal (transfollicular) elimination of connective-tissue elements and cellular debris.
What are the 3 connective tissue disorders?
Connective tissue diseases include autoimmune diseases like rheumatoid arthritis, scleroderma and lupus.
What is a perforating disorder?
Perforating disorders are characterized by transepidermal elimination of altered keratin or dermal connective tissue material. These disorders include perforating folliculitis (as shown below), Kyrle disease, elastosis perforans serpiginosa, reactive perforating collagenosis, and acquired perforating dermatosis.
What blood tests show connective tissue disease?
Routine screening tests for undifferentiated connective-tissue disease (UCTD) should include the following:
- Complete blood count.
- Erythrocyte sedimentation rate (ESR)
- C-reactive protein (CRP)
- Urinalysis with microscopic analysis.
- Serum creatinine.
- Rheumatoid factor (RF)
What are signs of connective tissue disorder?
Symptoms
- General feeling of being unwell. This can include increased fatigue and a mild fever.
- Cold and numb fingers or toes (Raynaud’s phenomenon). In response to cold or stress, your fingers or toes might turn white and then purplish blue.
- Swollen fingers or hands.
- Muscle and joint pain.
- Rash.
What is perforating dermatosis?
The perforating dermatoses represent a group of skin disorders characterized by the “perforation,” or elimination, of dermal connective tissue through the epidermis.
What doctor treats connective tissue disorders?
Whenever possible, a rheumatologist experienced in diagnosis and treatment of the disease should co-manage all patients with mixed connective-tissue disease (MCTD).
What is the most common connective tissue disorder?
Rheumatoid Arthritis (RA): Rheumatoid arthritis is one of the most common connective tissue diseases and can be inherited. RA is an autoimmune disease, meaning the immune system attacks its own body. In this systemic disorder, immune cells attack and inflame the membrane around joints.
Which syndrome is most strongly associated with connective tissue problems?
Marfan syndrome, also called arachnodactyly (“spider fingers”), is the most common of the hereditary disorders of connective tissue, having an estimated prevalence of about 15 cases per 1,000,000 population.